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Tuesday 20 September 2011

Synergism between cigarette smoke carcinogens and HPV - increased risk of cervical cancer progression

Synergism between cigarette smoke carcinogens and HPV - increased risk of cervical cancer progression


 Dr. Madhu Goel, Senior Consultant, Obst.& Gynecology at Rockland Hospital takes us through the disease in detail and what you can do to prevent it

There seem to be a synergism between cigarette smoke carcinogens and human papillomavirus. The article says that "Benzo[a]pyrene (BaP), a major carcinogen in cigarette smoke, had been detected in the cervical mucus and may bond well with HPV. This unhealthy exposure of cervical cells to high concentrations of BaP resulted in a 10-fold increase in HPV type 31 (HPV31) viral titers; whereas BaP exposure also increased HPV16 and HPV18 viral titers. Thus, the overall, BaP modulation of the HPV life cycle has potential to enhance viral persistence, host tissue carcinogenesis, and permissiveness for cancer progression". 

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