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Tuesday, 24 April 2012

Leptadenia pyrotechnica as an Anti-inflammatory and Anti-Cancer

In this research, the aqueous ethanolic crude extract of Leptadenia pyrotechnica aerial parts were evaluated for their antioxidant capacity, polyphenolic content, anti-inflammatory and anti-cancer properties. The extract showed appreciable anti-inflammatory via lipoxygenase (LOX) inhibitory activity (IC50 = 1.41 µg/mL). Moreover, the ethyl acetate fraction also showed the strongest cytotoxic effect (IC50 = 43.16 µg/mL) against MCF-7 human breast cancer cell line. These results suggest that this plant may be considered an interesting source of compounds with antioxidant, anti-inflammatory and anti-cancer properties for therapeutic, nutraceutical and functional food applications.